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- W2383455216 abstract "Aim:To investigate the roles of p38α signaling pathway in regulation of the transcription activity of a human endothelial nitric oxide synthase(eNOS) promoter by using p38α-targeting siRNA in a human vascular endothelial cell line(HUVEC-12). Methods: Expression of p38α protein in the HUVEC-12 cells treated with the siRNA was measured by Western blotting,and the optimal effecting time and optimal concentration of the siRNA were determined.Then,dual-luciferase reporter gene assay was employed to determine the fluorescence intensity of the lysate from the HUVEC-12 cells treated with the siRNA and thereby the activity of the eNOS promoter was analyzed.Results: Compared with the control,the expression of p38α was significantly weakened by interference of p38α-targeting siRNA,and accordingly the corresponding activity of eNOS promoter was up-regulated especially in the group with 100 mM siRNA-p38α for 48 hours.Conclusion:The siRNA interfering with p38α signal can up-regulate the transcriptional activity of the human eNOS promoter." @default.
- W2383455216 created "2016-06-24" @default.
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- W2383455216 date "2010-01-01" @default.
- W2383455216 modified "2023-09-26" @default.
- W2383455216 title "Up-regulation of the transcriptional activity of human eNOS promoter by siRNA interfering with p38α" @default.
- W2383455216 hasPublicationYear "2010" @default.
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