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- W2383465524 abstract "Objective To evaluate the effects of Ad-Runx3 on the migration and invasion of PC-3 cells.Methods The prostate cancer cell line PC-3 was divided into two groups: the experimental group(infected by Ad-Runx3) and control group(infected by Ad-EGFP). The expression of Runx3-flag was detected by western blot and located in cell nucleus by Indirect immunofluorescence. Cancer cell growth, migration and invasion capability of PC-3 were studied by MTT, transwell migration and Matrigel invasion assay respectively. Results The expression of Runx3-flag was detected and located in cell nucleus. Overexpression of Runx3 mediated by adenovirus had an inhibitory effect on the growth, migration and invasion of PC-3 cells. Conclusions The expression of Runx3-flag is detected and located in cell nucleus of PC-3 cells. Overexpression of Runx3 mediated by adenovirus has an inhibitory effect on the growth, migration and invasion of PC-3 cells in vitro, which casts new lights on the treatment of prostate cancer." @default.
- W2383465524 created "2016-06-24" @default.
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- W2383465524 date "2013-01-01" @default.
- W2383465524 modified "2023-09-25" @default.
- W2383465524 title "Effects of recombinant adenovirus Ad-Runx3 on human prostate cancer cells migration and invasion" @default.
- W2383465524 hasPublicationYear "2013" @default.
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