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- W2383501517 abstract "[Objective] To observe the serum levels of tumor necrosis factor alpha(TNF-α),glutathion(GTH) and malonaldehyde(MDA) in obesity-prone(OP) and obesity-resistant(OR) SD rats induced by high fat diet.[Methods] 25 male SD rats were randomly divided into high-fat diet group(n=21) and control group(n=9),and were fed with high-fat diet and normal diet for 24 weeks,respectively.The rats fed with high-fat diet were further divided into OP(n=7) and OR(n=7) subgroups,according to the body weight.The serum TNF-α,GTH and MDA levels were determined by ELISA.[Results] Both body weight and total fat weight in OP group were significantly higher than those in OR and control groups,respectively,(P﹤0.05).Although the bodyweight in OR group showed decreased tendency compared with that in control group,no significant difference was observed.Serum TNF-α levels in OP and OR groups were higher than those in control group,respectively,(P﹤0.05),while there was no significant difference of them between OP and OR groups(P﹥0.05).Serum GTH levels in OP group was lower(P﹤0.05),whereas they were tended to be reduced in OR group(P=0.059),when compared with those of controls,respectively.There was no significant difference of them between OP and OR groups.Serum MDA levels in both OP and OR subgroups were tended to be increased compared with those of controls(P﹥0.05).[Conclusion] There is no significant difference in body weight of rats between OR and control groups,however,high fat diet could lead to in vivo inflammatory reaction and oxidative stress." @default.
- W2383501517 created "2016-06-24" @default.
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- W2383501517 date "2009-01-01" @default.
- W2383501517 modified "2023-09-29" @default.
- W2383501517 title "STUDY OF SERUM TNF-Α,GTH AND MDA LEVELS IN OBESITY-PRONE AND OBESITY-RESISTANT RATS INDUCED BY HIGH FAT DIET" @default.
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