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- W2383503988 abstract "Objective To investigate the effects of endogenous nitric oxide (NO) on pancreatic microvascular permeability in rats with acute necrotizing pancreatitis (ANP). Methods ANP was induced in rats with retrograde infusion of 5% sodium taurocholate into the pancreatobiliary duct (1 ml/kg body weight). NG nitro L arginine (L NNA) was used as the inhibitor of endogenous NO and pancreatic microvascular permeability was determined by measurement of extravasation of Evans Blue to investigate the effects of endogenous NO on pancreatic injury and Evans Blue extravasation. Results Sodium taurocholate infusion induced evident pancreatic acinar necrosis and infiltration of inflammatory cells. Meanwhile, both serum amylase and pancreas wet/dry weight ration were increased and a marked accumulation of Evans Blue in pancreatic tissue was observed. Pretreatment with the NO inhibitor, L NNA (12 5 mg/kg body weight), significantly intensified acinar necrosis and infiltration of inflammatory cells and increased serum amylase, pancreas wet/dry weight ration and Evans Blue extravasation. Concurrent administration of L arginine, the substrate for NO synthesis, markedly reversed all of the above effects of L NNA. Conclusions Endogenous NO can protect the pancreas and its ability to maintain the pancreatic microvascular integrity may be involved in its protective mechanisms." @default.
- W2383503988 created "2016-06-24" @default.
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- W2383503988 date "2001-01-01" @default.
- W2383503988 modified "2023-09-23" @default.
- W2383503988 title "Effects of endogenous nitric oxide on pancreatic microvascular permeability in rats with acute necrotizing pancreatitis" @default.
- W2383503988 hasPublicationYear "2001" @default.
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