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- W2383535346 abstract "OBJECTIVE To establish a HPLC assay for the determination of diclofenac sodium in aqueous humor following its topical application in rabbits.METHOOS After methanol extraction,the residue was analyzed using a reversed phase C 18 column with methanol water acetic acid(80∶20∶0.5) as the mobile phase under ultraviolet detection.The aqueous humor samples obtained from rabbits at different interval were mesured.RESULTS The good linearity was achieved over the range of 10～50 ng·mL -1 .The mean recovery of three concentrations were 99.7% .The within and between day RSD was less than 10%.Diclofenac sodium was absorbed well through the aqueous humor with the peak concentration at 1 h.CONCLUSION The method was simple, sensitive, accurate and reproducible.It should be applicable for the determination of diclofenac sodium in ocular fluids." @default.
- W2383535346 created "2016-06-24" @default.
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- W2383535346 date "2001-01-01" @default.
- W2383535346 modified "2023-09-23" @default.
- W2383535346 title "Absorption of diclofenac sodium in aqueous humor after ocular administration in rabbits" @default.
- W2383535346 hasPublicationYear "2001" @default.
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