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- W2383540422 abstract "The work is to investigate effects of AdCMV-p53 gene transfer induced by 60Co γ-rays on cell cycles of human colorectal adenocarcinoma cells. HT-29 cells exposed to 0.5, 1.0 and 2.0 Gy were infected with AdCMV-GFP, a replication deficient recombinant adenoviral vector containing a CMV promoter and green fluorescent protein, or AdCMV-p53, a replication deficient recombinant adenoviral vector containing a CMV promoter and carrying human wild-type p53 gene. Survival rate of the cells was determined by clonogenic assay. Cell cycle and cell apoptosis were determined by flow cytometry. The results showed that, 0.5-1.0 Gy irradiation significantly enhanced the inhibition of AdCMV-p53 infection on HT-29. Compared with the control, 1day after the infection, the cells in G0/G1 phase decreased by 5 %-15 %, the cells in S phase increased by 2 %-19 %. The 0.5 and 1.0 Gy irradiation made the cells in the in G2/M phase increase by 12 %, infected with 80 MOI AdCMV-p5. Three days later, the proportion of cells in G2/M phase in groups of 0.5 and 1.0 Gy irradiation + 40 MOI AdCMV-p53 infection increased by 10%-13 %. There was a relation between cell apoptosis and irradiation dose, or AdCMV-p53 dose. Therefore, the irradiation-induction could quicken the progression from G0/G1 phase to S phase, and promote S and G2/M phase arrest." @default.
- W2383540422 created "2016-06-24" @default.
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- W2383540422 date "2006-01-01" @default.
- W2383540422 modified "2023-09-23" @default.
- W2383540422 title "Effects of AdCMV-p53 gene transfer induced by irradiation on cycle of human colorectal adenocarcinoma cells" @default.
- W2383540422 hasPublicationYear "2006" @default.
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