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- W2383547638 abstract "OBJECTIVE:To review regulation mechanisms of EMT and reveal the relationship between EMT and tumor metastasis.METHODS:The literature about EMT and tumor metastasis was searched in PubMed and CNKI from 2004 to 2008.Retrieval criterion:1)the regulation mechanisms of EMT;2)the relationship between EMT and tumor metastasis.About 60 articles were selected and according to the retrieval criterion 33 were refined finally.RESULTS:EMT exists in many physiological and pathological processes in human body.The regulation mechanisms of EMT involve E-cadherins,transforming growth factor β,wnt signal,transcription factors,microRNA and so on.Cells undergoing EMT possess stem cells property.CONCLUSIONS:EMT is correlated with tumor metastasis,and tumor cells transfer to distal tissues,which gain invasiveness by EMT.Subsequently,mesenchymal cells revert to epithelial cells by MET that tumor cells acquire proliferation again which provide a guarantee for tumor metastasis." @default.
- W2383547638 created "2016-06-24" @default.
- W2383547638 creator A5036134333 @default.
- W2383547638 date "2010-01-01" @default.
- W2383547638 modified "2023-09-24" @default.
- W2383547638 title "Epithelial-mesenchymal transitions and tumor metastasis" @default.
- W2383547638 hasPublicationYear "2010" @default.
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