Matches in SemOpenAlex for { <https://semopenalex.org/work/W2383577794> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2383577794 abstract "OBJECTIVE To construct the population pharmacokinetic(PPK) model of tinidazole in five major ethnic populations in China for individualized drug therapy in clinical practice.METHODS The population pharmacokinetic model of tinidazole was developed for 50 healthy subjects from Han,Mongol,Korean,Hui and Uighur nationality,the major 5 nationalities of China after oral administration.The effects of demography and biochemical covariates were investigated by NONMEM.Internal and external validations were conducted for the model.RESULTS A two-compartment model with first-order absorption and elimination process was confirmed as structure model of tinidazole.The population typical values and relative standard errors(RSE) of CL1,CL2,V1,V2 and Ka were 0.807(10.7%)L·h-1,205(9.32%)L·h-1,3.29(17.7%)L,19.0(15.4%)L and 1.51(8.28%) h-1 respectively.The result showed that race and body weight covariates showed significant influence on CL1(P0.001).Race and gender covariates showed significant influence on V1(P0.001).Body weight covariate showed significant influence on V2(P 0.001).CONCLUSION The final PPK model of tinidazole in for 5 major Chinese nationalityies was established by NONMEM.The PPK model was steady and reliable." @default.
- W2383577794 created "2016-06-24" @default.
- W2383577794 creator A5038935592 @default.
- W2383577794 date "2009-01-01" @default.
- W2383577794 modified "2023-09-25" @default.
- W2383577794 title "Population Pharmacokinetics of Tinidazole in Five Different Ethnic Populations of China" @default.
- W2383577794 hasPublicationYear "2009" @default.
- W2383577794 type Work @default.
- W2383577794 sameAs 2383577794 @default.
- W2383577794 citedByCount "0" @default.
- W2383577794 crossrefType "journal-article" @default.
- W2383577794 hasAuthorship W2383577794A5038935592 @default.
- W2383577794 hasConcept C105795698 @default.
- W2383577794 hasConcept C112705442 @default.
- W2383577794 hasConcept C119043178 @default.
- W2383577794 hasConcept C126322002 @default.
- W2383577794 hasConcept C137403100 @default.
- W2383577794 hasConcept C144024400 @default.
- W2383577794 hasConcept C149923435 @default.
- W2383577794 hasConcept C19165224 @default.
- W2383577794 hasConcept C2776239304 @default.
- W2383577794 hasConcept C2777396551 @default.
- W2383577794 hasConcept C2780626017 @default.
- W2383577794 hasConcept C2908647359 @default.
- W2383577794 hasConcept C3020755252 @default.
- W2383577794 hasConcept C33923547 @default.
- W2383577794 hasConcept C501593827 @default.
- W2383577794 hasConcept C54355233 @default.
- W2383577794 hasConcept C556039675 @default.
- W2383577794 hasConcept C71924100 @default.
- W2383577794 hasConcept C86803240 @default.
- W2383577794 hasConcept C98274493 @default.
- W2383577794 hasConcept C99454951 @default.
- W2383577794 hasConceptScore W2383577794C105795698 @default.
- W2383577794 hasConceptScore W2383577794C112705442 @default.
- W2383577794 hasConceptScore W2383577794C119043178 @default.
- W2383577794 hasConceptScore W2383577794C126322002 @default.
- W2383577794 hasConceptScore W2383577794C137403100 @default.
- W2383577794 hasConceptScore W2383577794C144024400 @default.
- W2383577794 hasConceptScore W2383577794C149923435 @default.
- W2383577794 hasConceptScore W2383577794C19165224 @default.
- W2383577794 hasConceptScore W2383577794C2776239304 @default.
- W2383577794 hasConceptScore W2383577794C2777396551 @default.
- W2383577794 hasConceptScore W2383577794C2780626017 @default.
- W2383577794 hasConceptScore W2383577794C2908647359 @default.
- W2383577794 hasConceptScore W2383577794C3020755252 @default.
- W2383577794 hasConceptScore W2383577794C33923547 @default.
- W2383577794 hasConceptScore W2383577794C501593827 @default.
- W2383577794 hasConceptScore W2383577794C54355233 @default.
- W2383577794 hasConceptScore W2383577794C556039675 @default.
- W2383577794 hasConceptScore W2383577794C71924100 @default.
- W2383577794 hasConceptScore W2383577794C86803240 @default.
- W2383577794 hasConceptScore W2383577794C98274493 @default.
- W2383577794 hasConceptScore W2383577794C99454951 @default.
- W2383577794 hasLocation W23835777941 @default.
- W2383577794 hasOpenAccess W2383577794 @default.
- W2383577794 hasPrimaryLocation W23835777941 @default.
- W2383577794 hasRelatedWork W1759772161 @default.
- W2383577794 hasRelatedWork W1988234374 @default.
- W2383577794 hasRelatedWork W2021205408 @default.
- W2383577794 hasRelatedWork W2025418172 @default.
- W2383577794 hasRelatedWork W2035232379 @default.
- W2383577794 hasRelatedWork W2080927791 @default.
- W2383577794 hasRelatedWork W2087821742 @default.
- W2383577794 hasRelatedWork W2142486974 @default.
- W2383577794 hasRelatedWork W2164447616 @default.
- W2383577794 hasRelatedWork W2358216406 @default.
- W2383577794 hasRelatedWork W2375386069 @default.
- W2383577794 hasRelatedWork W2382344173 @default.
- W2383577794 hasRelatedWork W2386666115 @default.
- W2383577794 hasRelatedWork W2388406655 @default.
- W2383577794 hasRelatedWork W2389210594 @default.
- W2383577794 hasRelatedWork W2411965389 @default.
- W2383577794 hasRelatedWork W2568485809 @default.
- W2383577794 hasRelatedWork W2942080013 @default.
- W2383577794 hasRelatedWork W2968981231 @default.
- W2383577794 hasRelatedWork W2187531079 @default.
- W2383577794 isParatext "false" @default.
- W2383577794 isRetracted "false" @default.
- W2383577794 magId "2383577794" @default.
- W2383577794 workType "article" @default.