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- W2383583018 abstract "Objective:To explore the effect of hydroxycamptothecin(HCPT) on hypoxia-induced expression of hypoxia inducible factor 1alpha(HIF-1α) and vascular endothelial growth factor(VEGF) genes in cervical cancer SiHa cells.Methods:Human cervical cancer SiHa cells were cultured under hypoxic conditions(37℃,5% CO2,1% O2) in vitro.The cultured cells were treated with different concentrations of HCPT for 24 h.The mRNA and protein expression of HIF-1α and VEGF were determined by semiquantitive RT-PCR and Western blot,respectively.The SiHa cells were also treated with HCPT under normal oxygen condition.SiHa cells in hypoxic control group were cultured under hypoxic conditions only.Results:There was no significant difference in the cytotoxicity induced by HCPT between hypoxic groups and normal control group.Under normal condition,SiHa cells did not express HIF-1α protein but weakly expressed VEGF protein.HCPT had no obvious effect on expression of HIF-1α and VEGF genes.Hypoxia significantly induced up-regulation of the expression of HIF-1α and VEGF.HCPT had significant inhibitory effects on the protein expression of HIF-1α and mRNA and protein expression of VEGF induced by hypoxia in a dose-dependent manner but had no obvious influence on mRNA expression of HIF-1α.Conclusion:HCPT inhibits hypoxia-induced over-expression of HIF-1α protein and the downstream VEGF gene in SiHa cells." @default.
- W2383583018 created "2016-06-24" @default.
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- W2383583018 date "2007-01-01" @default.
- W2383583018 modified "2023-09-27" @default.
- W2383583018 title "Effect of hydroxycamptothecin on hypoxia-induced expression of HIF-1α and VEGF genes in SiHa cells" @default.
- W2383583018 hasPublicationYear "2007" @default.
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