Matches in SemOpenAlex for { <https://semopenalex.org/work/W2383589567> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2383589567 abstract "Objective To explore the effect of insulin plus Vitamin C on delayed cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH). Methods Thirty-five male New Zealand white rabbits were randomized to four groups: control group (n=5), SAH group (n=10), insulin treatment group (n=10) and combined treatment with vitamin C and insulin group (n=10). SAH was induced by injecting blood into the cistern magna of rabbit 2 times. The treatment with insulin was started in the 3rd group and that with Vitamin C + insulin in the 4th group at 30 minutes after the first injecting blood, and lasting up to the end of this experiment. The rabbits were sacrificed by perfusion-fixation and the basilar artery and part of adjacent brain tissue were taken on the 5th day. The degree of CVS was evaluated by measuring the cross-sectional area of the basilar arterial lumen after hematoxylin and eosin staining, and the expression of insulin receptors in the vascular wall was examined by immunohistochemical staining. Results The mean value of cross-sectional area of the arterial lumen in the combined treatment group was 410 688.90±19 618.13μm2, while that of the control group was 462 107.90±42 999.40μm2. There was no significant difference between the two groups. The mean value of cross-sectional area of the arterial lumen in the SAH group was 236 486.37±8 721.3μm2 and that of the insulin group was 245 787.8±23 878.1 μm2. There was a significant difference between the control group and the SAH group or insulin group. Expression of insulin receptor was down-regulated significantly in the SAH group and insulin group on the vascular endothelial cell, and up-regulated markedly in the combined treatment group. Conclusion Combined use of vitamin C and insulin, not insulin alone, can effectively improve spasm of the cerebral vasculature after SAH." @default.
- W2383589567 created "2016-06-24" @default.
- W2383589567 creator A5087458915 @default.
- W2383589567 date "2007-01-01" @default.
- W2383589567 modified "2023-09-25" @default.
- W2383589567 title "Effect of combined use of insulin and antiscorbic acid on cerebral vasospasm after subarachnoid hemorrhage" @default.
- W2383589567 hasPublicationYear "2007" @default.
- W2383589567 type Work @default.
- W2383589567 sameAs 2383589567 @default.
- W2383589567 citedByCount "0" @default.
- W2383589567 crossrefType "journal-article" @default.
- W2383589567 hasAuthorship W2383589567A5087458915 @default.
- W2383589567 hasConcept C126322002 @default.
- W2383589567 hasConcept C131631996 @default.
- W2383589567 hasConcept C134018914 @default.
- W2383589567 hasConcept C2776820941 @default.
- W2383589567 hasConcept C2777736543 @default.
- W2383589567 hasConcept C2778506911 @default.
- W2383589567 hasConcept C2779306644 @default.
- W2383589567 hasConcept C2779537118 @default.
- W2383589567 hasConcept C2781012200 @default.
- W2383589567 hasConcept C42219234 @default.
- W2383589567 hasConcept C71924100 @default.
- W2383589567 hasConceptScore W2383589567C126322002 @default.
- W2383589567 hasConceptScore W2383589567C131631996 @default.
- W2383589567 hasConceptScore W2383589567C134018914 @default.
- W2383589567 hasConceptScore W2383589567C2776820941 @default.
- W2383589567 hasConceptScore W2383589567C2777736543 @default.
- W2383589567 hasConceptScore W2383589567C2778506911 @default.
- W2383589567 hasConceptScore W2383589567C2779306644 @default.
- W2383589567 hasConceptScore W2383589567C2779537118 @default.
- W2383589567 hasConceptScore W2383589567C2781012200 @default.
- W2383589567 hasConceptScore W2383589567C42219234 @default.
- W2383589567 hasConceptScore W2383589567C71924100 @default.
- W2383589567 hasLocation W23835895671 @default.
- W2383589567 hasOpenAccess W2383589567 @default.
- W2383589567 hasPrimaryLocation W23835895671 @default.
- W2383589567 hasRelatedWork W1932303298 @default.
- W2383589567 hasRelatedWork W2028175874 @default.
- W2383589567 hasRelatedWork W2029516664 @default.
- W2383589567 hasRelatedWork W2048481431 @default.
- W2383589567 hasRelatedWork W2076478851 @default.
- W2383589567 hasRelatedWork W2297528170 @default.
- W2383589567 hasRelatedWork W2390223608 @default.
- W2383589567 hasRelatedWork W2414213062 @default.
- W2383589567 hasRelatedWork W2415833148 @default.
- W2383589567 hasRelatedWork W2743438430 @default.
- W2383589567 hasRelatedWork W2759036013 @default.
- W2383589567 hasRelatedWork W2794699880 @default.
- W2383589567 hasRelatedWork W2891966436 @default.
- W2383589567 hasRelatedWork W3030902128 @default.
- W2383589567 hasRelatedWork W3030969773 @default.
- W2383589567 hasRelatedWork W3030970022 @default.
- W2383589567 hasRelatedWork W3032382382 @default.
- W2383589567 hasRelatedWork W3032600806 @default.
- W2383589567 hasRelatedWork W3150785449 @default.
- W2383589567 hasRelatedWork W4173975 @default.
- W2383589567 isParatext "false" @default.
- W2383589567 isRetracted "false" @default.
- W2383589567 magId "2383589567" @default.
- W2383589567 workType "article" @default.