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- W2383589737 abstract "objective:To study the role of granulocyte-macrophage colony stimulating factor(GM-CSF) in acute pancreatitis associated lung injury and the mechanism of yiyan mixtures in treating lung injury.Methods: 120 healthy wistar rats were randomly divided into 4 groups: model group,treatment group with yiyan mixtures,treatment group with Ulinastain(UTI) and negative contral group.The model of acute lung injury was estabished with retrograde injection of 5% sodium taurocholate in biliopancreatic duct in rats.The ratio of wet and dry lung(W/D),the activity of lung myeloperoxidase(MPO) and the level of GM-CSF at various times were analyzed.Results: In model group,the levels of GM-CSF,MPO and W/D were significantly increased(P0.01),and reached to its peak between 12 and 24 hours.The levels of GM-CSF,MPO and W/D at various times except for 6 hour showed no difference between two treatment group(P0.05).MPO and W/D ar were positively correlated with GM-CSF in model group and treatment group(r=0.6661;r=0.7668;P0.01).MPO is also positively correlated with W/D(r=0.5706,P0.01).Conclusion: GM-CSF may improve the neutrophil aggregating in lung,which plays a key role in the development of acute pancreatitis associated lung injury.Yiyan mixtures are effective in relieving the acute pancreatitis associated lung in jury though in babiting the production of GM-CSF." @default.
- W2383589737 created "2016-06-24" @default.
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- W2383589737 date "2007-01-01" @default.
- W2383589737 modified "2023-09-25" @default.
- W2383589737 title "The Role of GM-CSF in Acute Pancreatitis Associated Lung Injury and Interventional Medication" @default.
- W2383589737 hasPublicationYear "2007" @default.
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