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- W2383600524 abstract "AIM: To investigate the role of Gαq/11-mediated signal transduction pathway in cardiac hypertrophy induced by angiotensin II (AngII). METHODS: Renal hypertension was performed by placing a sliver clip around the left renal artery(2K1C). Hemodynamic parameters, the ratio of left ventricular weight to body weight, the AngII contents and the activities of phospholipase C (PLC) in myocardium were measured at 1st, 2nd, 4th and 8th week after operation, respectively. The levels of Gαq/11 were assayed by Western blot analysis. -leucine incorporation and levels of Gαq/11 were measured in cultured neonatal rats ventricular myocyte after AngII stimulation. RESULTS: In 2K1C group, blood pressure and the ratio of left ventricle of heart to body weight were significantly increased compared with sham group between 2nd to 8th week. AngII content increased from 1st to 8th week after operation. Compared with the sham group, levels of Gαq/11 in 2K1C group increased by 25.0% and 35.8% at 4th and 8th week( P 0 05), respectively. PLC activities of 2K1C group were significantly increased at 2nd, 4th, and 8th week ( P 0 05). Gαq/11 protein levels was upregulated in myocyte stimulated by AngII and this effect presented before the increasing of -leucine incorporation. CONCLUSION: Activation of the Gαq/11-mediated signal transduction pathway plays an important role in cardiac hypertrophy induced by AngII." @default.
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- W2383600524 date "2002-01-01" @default.
- W2383600524 modified "2023-09-25" @default.
- W2383600524 title "Effect of Gαq/11-mediated signal transduction pathway in cardiac hypertrophy induced by angiotensin II" @default.
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