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- W2383605820 abstract "Objective To study the roles of TNF-α and TNFR1 in the induction and development of acute hepatic failure.Method Seventy-two male mice were divided into three groups randomly,the model group were induced by TNF-α and D-Ga1N.The levels of ALT、AST and TNF-α were measured by biochemical assay and ELISA kit,respectively.The histopathological change was observed by HE and TUNEL.Results It was found that the serum levels of ALT,AST and TNF-α in the model were apparently increased compared with those in control group(P0.05),and profuse apoptosis and necrosis were emerged in hepatocytes when tested by TUNEL and HE method.However,in the treatment group,the serum levels of TNF-α were decreased and the liver injury was remarkably ameliorated based on the serum transaminase levels(P0.05) and histological change.Conclusions TNF-α is an important role in acute hepatic failere,anti-TNFR1-Ab treatment can partially block the liver injury induced by TNF-α and D-Ga1N and ameliorate the hepatic histopathological change,so anti-TNFR1-Ab treatment provides the basis for a novel therapeutic modality in which an unfavorable apoptotic process can be inhibited in acute hepatic failure mice." @default.
- W2383605820 created "2016-06-24" @default.
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- W2383605820 date "2007-01-01" @default.
- W2383605820 modified "2023-09-28" @default.
- W2383605820 title "The induction of TNF-α and TNFR1 in acute hepatic failure mice hepatocyte" @default.
- W2383605820 hasPublicationYear "2007" @default.
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