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- W2383610497 abstract "Objective To investigated the role of PI3K/Akt pathway involved in renal ischemia/reperfusion injury in mice.Methods There were a total of 3 experimental groups.The sham-operative group was with 6 mice.The control and wortmannin-treated groups subjected to renal injury were similarly studied at 30min,90min,24h,48h(n=6) following reperfusion.Wortmannin or its vehicle was given intraperitoneally at 4 hours before mice were subjected to surgery.The clamping duration was thirty-five minutes.At above time points after reperfusion,serum creatinine,BUN and renal pathological changes were tested and compared among the three groups.Expressions of p27 and PCNA proteins were examined by immunohistochemistry.Results Wortmannin had a deleterious effect on serum creatinine and BUN values,renal impairments after renal ischemia-reperfusion injury of mice.The renal cell proliferation increased after ischemia/reperfusion injury in mouse,which could be inhibited by wortmannin.Renal p27 level significantly decreased in the wortmannin-treated group.Conclusions The study suggests that PI3-kinase/Akt signal pathway play an important role in regulating the repair following renal ischemia/reperfusion injury." @default.
- W2383610497 created "2016-06-24" @default.
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- W2383610497 date "2006-01-01" @default.
- W2383610497 modified "2023-09-24" @default.
- W2383610497 title "Effects of PI3-kinase inhibitor Wortmannin on renal function,expression of p27 and PCNA after ischemia/reperfusion injury in mouse kidney" @default.
- W2383610497 hasPublicationYear "2006" @default.
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