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- W2383615648 abstract "Objective: To study the effect of intrathecal injection of carbenoxolone on the rat paw withdrawal thermal latency. Methods: Experimental rats were intrathecally injected with carbenoxolone(CBX), a special gap junction blocker, and the control rats with the saline. Before and 2 h after intrathecal injection,each rat was examined for the paw withdrawal thermal latency(PWTL).Afterwards,the corresponding serial sections of spinal cord were processed for anti Fos, anti GFAP immunohistochemistry staining. Results: The PWTLs were 14.42 s±1.16 s in the experimental group and 14.58 s ±1.37 s in the control group before the injection. After the treatment with CBX or saline the PWTLs changed to 27.78±2.53 and 16.84±1.74 respectively ( P 0.05). The immunohistochemical staining results were that the GFAP LI astrocytes presented similar expression in the animals with or without the CBX injection, while the expression of Fos LI neurons significantly decreased than that of the control. Conclusion: The hindpaw thermal latency significantly ascended and the threshold of pain obviously went up. The gap junction may play an important role in process of pain induced by the peripheral injury,and astrocytes may be involved in modulation of pain via the gap junction. [" @default.
- W2383615648 created "2016-06-24" @default.
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- W2383615648 date "2003-01-01" @default.
- W2383615648 modified "2023-09-25" @default.
- W2383615648 title "Effect of intrathecal injection of carbenoxolone on rat paw withdrawal thermal latency" @default.
- W2383615648 hasPublicationYear "2003" @default.
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