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- W2383632614 abstract "【Objective】 This study investigated the mechanism of myocardial apoptosis and researched the effects of exercise on apoptosis of myocardial cell and nitric oxide synthase in rats.【Method】 Aerobic exercise group and overtraining group models were established based on swimming training.The rats in regular feeding group were set as control to detect changes of heart weight and heart coefficient in other groups.The expressions of p53 protein were detected by Western blot.The apoptosis of myocardial cell were detected by DNA ladder in tissue sections.Determination of NO content,cNOS and iNOS activity in rats myocardial and serum were measured by kit.【Result】 The heart weight and heart coefficient of rats in overload training group increased.The expression of p53 protein increased significantly in cardiac muscle cell after overtraining,which might have relation to genetic controls on apoptosis in myocardial cell.DNA ladder results showed that it had noticeably apoptosis strips after overload training.cNOS activity in myocardial and serum of rats in the aerobic exercise group increased,and generate a small amount of NO was generated,positively affecting cardiovascular system,but long term overload training could lead to too much NO,which had toxic effect on cell.【Conclusion】 Inappropriate exercises load will result in the increase of myocardial apoptosis,and NO may be involved in the process of myocardial damage." @default.
- W2383632614 created "2016-06-24" @default.
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- W2383632614 date "2013-01-01" @default.
- W2383632614 modified "2023-09-28" @default.
- W2383632614 title "Effect of exercise on myocardial cell and nitric oxide synthase in rats" @default.
- W2383632614 hasPublicationYear "2013" @default.
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