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- W2383641677 abstract "Objective: To observe the effect of Compound Soufeng Qutan Fang on unstable plaque HO-1 and HSP70 in Apo E gene knockout rats with atherosclerosis.Methods: The successful model of the Apo E- gene knockout rats were given low dose,medium-dose,high-dose Chinese herbal compound and western medicine for a month.At the same time,the model group was fed by normal saline for one month.After treatment for 13 weeks,levels including HO-1 and HSP70 were detected by immunohistochemistry and RT-PCR technique.Results:Compared with the blank group,the HO-1 and HSP70 expression levels in the model group were reduced(P 0.01).Compared with the model group,these expressions were increased in the western medicine group and the Wenban Tang group(P 0.01 or P 0.05).There were no statistical differences in the HO-1 and HSP70 expressions between the western medicine group and the Wenban Tang high-dose group(P﹥ 0.05).Conclusion: Compound Soufeng Qutan wenban Tang may stabilize plaques by regulating the expression of inflammatory factors and interfering the formation and rupture of AS plaque,which provides a new idea to prevent AS." @default.
- W2383641677 created "2016-06-24" @default.
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- W2383641677 date "2015-01-01" @default.
- W2383641677 modified "2023-09-24" @default.
- W2383641677 title "Study of Compound Soufeng Qutan Fang on Expression of Unstable Plaque HO-1 and HSP70 in Apo E Gene Knock-out Rats with Atherosclerosis" @default.
- W2383641677 hasPublicationYear "2015" @default.
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