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- W2383642029 abstract "Objective: To prepare sinomenine gel and study its skin penetration in vitro.Methods: Sinomenine gel was prepared with carbopol 980 as base material. Using improved Franz-type diffusion cell and isolated rat skin as transdermal barrier,the cumulative permeation quantity of sinomenine was determined by HPLC method.Results: The penetration equation of sinomenine gel was Q=65.852 t-55.677(r=0.991 9).The cumulative permeation quantity of sinomenine in 10 h was 638 μg/cm~2.Conclusion: A sinomenine gel was developed.The penetration of sinomenine from the gel through the rat skin follows first-order kinetics." @default.
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- W2383642029 date "2006-01-01" @default.
- W2383642029 modified "2023-09-25" @default.
- W2383642029 title "Preparation of sinomenine gel and its skin penetration test in vitro" @default.
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