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- W2383650574 abstract "Objective: To explore the character of drug release of multilayer microcapsules,some types of Indomethacin-ACA multilayer microcapsules were prepared with different prescription and its drug release in vitro was studied.Methods: ACA multilayer microcapsules were prepared using different crosslinking agent CaCl2,BaCl2and preparation process such as the capsule heart liquefaction,lyophilization,with indomethacin as model drug.The drug release in vitro was also inspected.Results: Indomethacin released much slowlier from ACA multilayer microcapsules than it from ACA single layer microcapsules,and the rate from ACA-Ba-Ba multilayer microcapsules was the slowest(18-21 h for 90% drug release).Capsule heart liquefaction could accelerate drug release rate slightly,and the lyophilization process made the drug release slowly.The amount of drug release in artificial gastric juice was less than 20% in 2 h,while in artificial intestinal juice it could be more than 90% in 1 h.Conclusion: ACA multilayer microcapsules can keep drug releasing slowly,it may be a new drug sustainedrelease dosage form." @default.
- W2383650574 created "2016-06-24" @default.
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- W2383650574 date "2013-01-01" @default.
- W2383650574 modified "2023-09-26" @default.
- W2383650574 title "Preparation of some types of ACA multilayer microcapsules and study on it’s drug release in vitro" @default.
- W2383650574 hasPublicationYear "2013" @default.
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