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- W2383652156 abstract "Abstract Estriol and estrone have been shown to stimulate bactericidal activity of myeloperoxidase (MPO)-containing 20,000 × g granule pellets obtained from guinea pig peritoneal polymorphonuclear leukocytes. Beta estradiol and progesterone were without effect. An MPO-mediated amino acid decarboxylation reaction, optimal at acidic pH and postulated as a mechanism involved with the bactericidal activity, was also stimulated by estriol and estrone but not by beta estradiol and progesterone. In contrast, no stimulation of MPO-mediated guaiacol oxidation at pH 7.0 was observed with any of these hormones. The stimulation of bactericidal activity by estriol and estrone was not observed if highly purified human MPO was substituted for the guinea pig MPO-containing 20,000 × g granule pellets. These observations suggest that estriol and estrone may be stimulating MPO-mediated bactericidal activity through an indirect mechanism. It is possible that hyperbactericidal leukocyte activity observed in pregnancy may be related, at least in part, to stimulation of its MPO-mediated bactericidal activity and amino acid decarboxylation by estriol and/or estrone." @default.
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- W2383652156 date "1973-11-01" @default.
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- W2383652156 title "The role of the phagocyte in host-parasite interactions" @default.
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- W2383652156 doi "https://doi.org/10.1016/0002-9378(73)90209-3" @default.
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