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- W2383660399 abstract "Objective The purpose of this study was to investigate the effect of inhibition of EGFR expression by RNA interference on radiation-induced apoptosis and necrosis in human nasopharyngeal carcinoma CNE2 cells.Methods EGFR-shRNA as well as various controls was transfected into human nasopharyngeal carcinoma CNE2 cells.The proliferation of irradiated cells was detected by MTT assay.The ratio of apoptosis and necrosis of CNE2 cells was detected by Annexin V /PI staining.Results EGFR-shRNA was effectively delivered into nasopharyngeal carcinoma cells.Proliferation of irradiated CNE2 cells was significantly decreased after EGFRshRNA interference.Apoptosis and necrosis rate of irradiated CNE2 cells increased after EGFR-shRNA interference,and the proportion of apoptosis cells was more than the proportion of necrosis cells.Conclusion Radiation-induced apoptosis was one of the mechanisms of radiation-induced proliferation inhibition of EGFRshRNA interference nasopharyngeal carcinoma cells." @default.
- W2383660399 created "2016-06-24" @default.
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- W2383660399 date "2012-01-01" @default.
- W2383660399 modified "2023-09-23" @default.
- W2383660399 title "The effect of inhibition of EGFR expression by RNA interference on apoptosis and necrosis in nasopharyngeal carcinoma cells" @default.
- W2383660399 hasPublicationYear "2012" @default.
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