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- W2383663734 abstract "In order to find out the mechanism of manganese-induced neurotoxicity,the activities levels of lipid peroxidation and its enzyme in SH-SY5Y cells treated with manganese were studied. The SH-SY5Y cells were used as cell model and treated with manganese of bivalence and trivalence at concentrations of 0.25,0.50 or 0.75 mmol/L for 24 hours,respectively.The antioxidant system in SH-SY5Y cells was investigated by applying biochemical analysis such as enzyme activity detection. Mn(Ⅱ) and Mn(Ⅲ) treatment changed enzyme activities.The activities of Mn-SOD,GSH,GSH-Px and CAT are significantly lower than those in controls(P0.05,P0.01). The activities of Mn-SOD,GSH,GSH-Px and CAT were negatively correlated to the dose of manganese.While the content of MDA increased greatly as compared to normal controls(P0.01) and had a significant dose-response correlation. [Conclusion] The aggravation on lipid peroxidation and related activities in SH-SY5Y cells can be caused by manganese. The results in the study indicate that observed changes may be one of the important ways of manganese cytotoxicity." @default.
- W2383663734 created "2016-06-24" @default.
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- W2383663734 date "2004-01-01" @default.
- W2383663734 modified "2023-09-25" @default.
- W2383663734 title "The Effect of Manganese with Different Valences on Lipid Peroxidation in Human Neuroblastoma Cell Line SH-SY5Y" @default.
- W2383663734 hasPublicationYear "2004" @default.
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