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- W2383668129 abstract "OBJECTIVE To study the effect of Gn 3 on the LTD 4 receptor by using a radio ligand binding assay of LTD 4.METHODS Lung membrane of guinea pig was used as experimental materials, 3H LTD was used as radio ligand,FPL 55712 was chosen as the positive control drug,Gn 3 was used as the tested drug and bioassay in vitro was used to determine the biological function of Gn 3.RESULTS The binding of 3H LTD 4 to its receptor was specific,saturable and reversible.The K d and B max values were 19.9×10 -11 mol·L -1 and 232.9 fmol·mg -1 protein respectively at 30℃.Gn 3 inhibited 3H LTD 4 in competing against LTD 4 receptor.The IC 50 and K i value were 5.71×10 -7 mol·L -1 and 2.54×10 -7 mol·L -1 respectively.It was also determined that Gn 3 was LTD 4 receptor antagonist by the bioassay in vitro.CONCLUSION The binding of 3H LTD 4 on guinea pig lung membrane showed a single binding site.Gn 3 appeared to be an effective LTD 4 receptor antagonist." @default.
- W2383668129 created "2016-06-24" @default.
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- W2383668129 date "2000-01-01" @default.
- W2383668129 modified "2023-09-25" @default.
- W2383668129 title "Studies on the characteristics of LTD_4 receptor with radio-ligand binding assay and the effect of Gn-3" @default.
- W2383668129 hasPublicationYear "2000" @default.
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