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- W2383669248 abstract "Objective To explore the effect of preoperatively regional intraarterial infusion chemotherapy(PRAC) on the microvessel density (MVD) and the expression of vascular endothelial growth factor (VEGF) of tissures from colorectal cancer. Methods The MVD and the expression of VEGF were examined by immunohistochemistry method in cancerous tissues from 30 patients with PRAC and from 31 patients without PRAC. Results Mean MVD was 19.2±5.2 in the chemotherapeutic group, and 42.4±18.4 in the control group(P 0.01).Expression of VEGF protein was remarkably lower in chemotherapeutic group than that in the control group (P 0.01) . The expression of VEGF was correlated with MVD(r=0.788,P 0.05) . Conclusion PRAC may take effect by down regulating the expression of VEGF to reduce tumor angiogenesis or directly inhibiting tumor angiogenesis to inhibit the proliferation of cancer cells." @default.
- W2383669248 created "2016-06-24" @default.
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- W2383669248 date "2001-01-01" @default.
- W2383669248 modified "2023-09-25" @default.
- W2383669248 title "Influence of preoperatively regional intraarterial infusion chemotherapy on microvessel density and the expression of vascular endothelial growth factor in human colorectal carcinoma" @default.
- W2383669248 hasPublicationYear "2001" @default.
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