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- W2383669328 abstract "Definitions of mild cognitive impairment (MCI) vary, yielding conflicting results. For example, case definitions affect prevalence but not outcomes in prevalent cases. Our objective was to determine whether variation in case definitions affects outcomes in incident cases of MCI. The 5 year risks of death, institutionalisation, and dementia were evaluated in clinically examined incident MCI cases in the Canadian Study of Health and Aging. The definition of MCI was varied so as to include or relax combinations of diagnostic features from consensus criteria. Relative risks (RR) of each adverse outcome were highest in MCI case definitions that required subjective memory complaints (for example, RR of dementia=26.4-38.7). Although each MCI definition conferred an increased risk of dementia, for each case definition 20-30%of survivors had no cognitive impairment at follow up. In this population based study, MCI represented a transitional state, but was heterogeneous, with substantial proportions recovering, regardless of how MCI was defined. Factors associated with recovery and non-progression in MCI require elucidation." @default.
- W2383669328 created "2016-06-24" @default.
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- W2383669328 date "2005-01-01" @default.
- W2383669328 modified "2023-09-22" @default.
- W2383669328 title "Outcomes of incident mild cognitive impairment in relation to case definition" @default.
- W2383669328 hasPublicationYear "2005" @default.
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