Matches in SemOpenAlex for { <https://semopenalex.org/work/W2383686825> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2383686825 endingPage "1011" @default.
- W2383686825 startingPage "1006" @default.
- W2383686825 abstract "Objective To study the growth inhibitation action of gossypol derivatives,ApoG2 on the prostatic cancer PC-3 cells,and make the primary study about their anti-tumor mechanism.Methods The MTT analytical method,AO staining,transmission electron microscope,flow cytometer and Western blot for measuring the apoptosis related proteins were used to study the growth inhibition and induction of autophagy roles of ApoG2 on the prostatic cancer PC-3 cells in vitro.Results When the concentration of ApoG2 was higher than 2.5 μg/ml in solution,it had the obvious proliferation inhibition ability to the prostate cancer PC-3 cells in vitro,and it had the charcteristics of time and dose dependent.When ApoG2 was used for the treatment of PC-3 cell for 72 hours,the observation with AO staining and transmission electron microscope indicated that ApoG2 could obviously induce the autophagy of prostate cancer cells.The measurement results by the flow cytometer indicated that the apoptosis of prostate cancer cells induced by ApoG2 might be strengthened by the use of autophagic inhibitor 3-MA.The measurement of Bcl-2 expressions by the Western blot found that after ApoG2 at the concentration of 10.0 μg/ml was used for treatment of prostate cancer cells for 48 hours,the expression level of Bcl-2 decreased.The Beclin 1 and LC-3Ⅱexpressions in the tumor cells were obviously increased by immunohistochemistry method after ApoG2 treatment.Conclusion ApoG2 has the same obvious anti-proliferation role to the prostatic cancer PC-3 cells in vitro and its mechanism is to mainly induce the autophagy of tumor cells and to secondarily induce their death,the inhibition of autophagy may promote the occurrence of death." @default.
- W2383686825 created "2016-06-24" @default.
- W2383686825 creator A5009627592 @default.
- W2383686825 creator A5026922135 @default.
- W2383686825 creator A5040199296 @default.
- W2383686825 creator A5050035595 @default.
- W2383686825 creator A5053086703 @default.
- W2383686825 creator A5060716844 @default.
- W2383686825 creator A5074669391 @default.
- W2383686825 date "2011-09-25" @default.
- W2383686825 modified "2023-09-27" @default.
- W2383686825 title "Apogossypolone Induces Autophagy of PC-3 Prostate Cancer Cells in vitro" @default.
- W2383686825 doi "https://doi.org/10.3971/j.issn.1000-8578.2011.09.009" @default.
- W2383686825 hasPublicationYear "2011" @default.
- W2383686825 type Work @default.
- W2383686825 sameAs 2383686825 @default.
- W2383686825 citedByCount "0" @default.
- W2383686825 crossrefType "journal-article" @default.
- W2383686825 hasAuthorship W2383686825A5009627592 @default.
- W2383686825 hasAuthorship W2383686825A5026922135 @default.
- W2383686825 hasAuthorship W2383686825A5040199296 @default.
- W2383686825 hasAuthorship W2383686825A5050035595 @default.
- W2383686825 hasAuthorship W2383686825A5053086703 @default.
- W2383686825 hasAuthorship W2383686825A5060716844 @default.
- W2383686825 hasAuthorship W2383686825A5074669391 @default.
- W2383686825 hasConcept C104317684 @default.
- W2383686825 hasConcept C121608353 @default.
- W2383686825 hasConcept C126322002 @default.
- W2383686825 hasConcept C134018914 @default.
- W2383686825 hasConcept C185592680 @default.
- W2383686825 hasConcept C190283241 @default.
- W2383686825 hasConcept C202751555 @default.
- W2383686825 hasConcept C203014093 @default.
- W2383686825 hasConcept C203522944 @default.
- W2383686825 hasConcept C2776235491 @default.
- W2383686825 hasConcept C2776415932 @default.
- W2383686825 hasConcept C2780192828 @default.
- W2383686825 hasConcept C2781000418 @default.
- W2383686825 hasConcept C502942594 @default.
- W2383686825 hasConcept C553184892 @default.
- W2383686825 hasConcept C55493867 @default.
- W2383686825 hasConcept C71924100 @default.
- W2383686825 hasConcept C96232424 @default.
- W2383686825 hasConceptScore W2383686825C104317684 @default.
- W2383686825 hasConceptScore W2383686825C121608353 @default.
- W2383686825 hasConceptScore W2383686825C126322002 @default.
- W2383686825 hasConceptScore W2383686825C134018914 @default.
- W2383686825 hasConceptScore W2383686825C185592680 @default.
- W2383686825 hasConceptScore W2383686825C190283241 @default.
- W2383686825 hasConceptScore W2383686825C202751555 @default.
- W2383686825 hasConceptScore W2383686825C203014093 @default.
- W2383686825 hasConceptScore W2383686825C203522944 @default.
- W2383686825 hasConceptScore W2383686825C2776235491 @default.
- W2383686825 hasConceptScore W2383686825C2776415932 @default.
- W2383686825 hasConceptScore W2383686825C2780192828 @default.
- W2383686825 hasConceptScore W2383686825C2781000418 @default.
- W2383686825 hasConceptScore W2383686825C502942594 @default.
- W2383686825 hasConceptScore W2383686825C553184892 @default.
- W2383686825 hasConceptScore W2383686825C55493867 @default.
- W2383686825 hasConceptScore W2383686825C71924100 @default.
- W2383686825 hasConceptScore W2383686825C96232424 @default.
- W2383686825 hasIssue "9" @default.
- W2383686825 hasLocation W23836868251 @default.
- W2383686825 hasOpenAccess W2383686825 @default.
- W2383686825 hasPrimaryLocation W23836868251 @default.
- W2383686825 hasRelatedWork W1531380847 @default.
- W2383686825 hasRelatedWork W1774950549 @default.
- W2383686825 hasRelatedWork W2013383578 @default.
- W2383686825 hasRelatedWork W2018168223 @default.
- W2383686825 hasRelatedWork W2072819875 @default.
- W2383686825 hasRelatedWork W2109195553 @default.
- W2383686825 hasRelatedWork W2118901014 @default.
- W2383686825 hasRelatedWork W2147785508 @default.
- W2383686825 hasRelatedWork W2163563254 @default.
- W2383686825 hasRelatedWork W2168970080 @default.
- W2383686825 hasRelatedWork W2176094125 @default.
- W2383686825 hasRelatedWork W2365602272 @default.
- W2383686825 hasRelatedWork W2373018678 @default.
- W2383686825 hasRelatedWork W2373348560 @default.
- W2383686825 hasRelatedWork W2392318241 @default.
- W2383686825 hasRelatedWork W2615541226 @default.
- W2383686825 hasRelatedWork W2789298226 @default.
- W2383686825 hasRelatedWork W2911736468 @default.
- W2383686825 hasRelatedWork W3031606529 @default.
- W2383686825 hasRelatedWork W3096678640 @default.
- W2383686825 hasVolume "38" @default.
- W2383686825 isParatext "false" @default.
- W2383686825 isRetracted "false" @default.
- W2383686825 magId "2383686825" @default.
- W2383686825 workType "article" @default.