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- W2383691116 abstract "The migration of tumor cells into the lymph nodes is an important aspect of cancer.CC-chemokine receptor 7(CCR7) has been shown to play an important role in tumor cell migration and lymph node metastasis.In our study,ten truncated mutants of CC-chemokine ligand 21(CCL21) were constructed.mCCL21-a(1-57),a novel C-terminal deletion mutant of human CCL21,exhibited favorable antagonistic effect on CCL21-stimulated chemotaxis of human colorectal carcinoma cell line SW480 in the pre-screening assays.Prokaryotic expression system is used to express this mutant so as to further investigate its biological activity in vitro and in vivo.In the chemotaxis assays,SW480 cells exhibited CCL21-induced migration,but it was significantly suppressed by mCCL21-a(1-57) in a dose-dependent manner.Further observation illustrated that mCCL21-a(1-57) inhibits the activation of extracellular signal-regulated kinase(ERK) induced by CCL21.In summary,the C-terminal of CCL21 is essential for CCL21 mediated cell migration and activation of ERK and the mCCL21-a(1-57) was an effective antagonist of CCL21 in vitro." @default.
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- W2383691116 date "2011-01-01" @default.
- W2383691116 modified "2023-09-24" @default.
- W2383691116 title "mCCL21-a (1-57),a C-terminal Deletion Mutant of CCL21, Inhibits CCL21-mediated Migration in Cultured SW480 Cells by Suppressing ERK Activation" @default.
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