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- W2383703073 abstract "Objective:To study the mechanism of action of Yuxingeng Fluid(YXGF)in preventing and treating ventricular remodeling in a- cute myocardial infarction by means of observing the changes of endothelin(ET)and angiotensin Ⅱ(Ang Ⅱ)content in myocardium and plasma.Methods:After the left anterior descending coronary artery was ligated and the rat being proved to have acute myocardial infarction(AMI)by ST-T segment elevation in electrocardiogram(ECG),the rats with AMI were divided into 6 groups.The medica- tion by gastrogavage was started from the 2nd day after operation for successive 4 weeks.Then they were killed to observe the cardiac index,ventricular weight and the contents of ET,Ang Ⅱ in myocardial tissue and plasma.Results:As compared with the model group, in the YXGF high and middle dosage groups and the captopri group,the cardiac index,ventricular weight as well as ET and Ang Ⅱ in myocardial tissue and plasma were all lower(P0.05 or P0.01),and ET in myocardial tissue in the YXGF low dose group was also lower(P0.05).Conclusion:YXGF could lower the left vent ricular weight and cardiac index significantly in rat with AMI,the effects of it in lowering contents of ET and Ang Ⅱ in myocardial tissue and plasma might be one of the mechanisms in preventing and treating ventricular remodeling in early stage of AMI." @default.
- W2383703073 created "2016-06-24" @default.
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- W2383703073 date "2002-01-01" @default.
- W2383703073 modified "2023-09-23" @default.
- W2383703073 title "Study on Mechanism of Yuxingeng Fluid in Preventing and Treating Ventricular Remodeling in Rats with Acute Myocardial Infarction" @default.
- W2383703073 hasPublicationYear "2002" @default.
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