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- W2383703078 abstract "Objective To investigate the effect of dexmedetomidine on perioperative blood glucose variability and thromboxane A2/epoprostenol(TXA2/PGI2) balance in patients with high blood glucose and coronary heart disease.Methods Forty elderly patients,diagnosed with coronary heart disease and glycated hemoglobin(HbA1c)6.5%,ASA Ⅱ or Ⅲ,scheduled for elective lower limb surgery,were randomly divided into two groups:group D(n=20) and group C(n=20).Group D received dexmedetomidine infusion before anesthesia induction until the end of operation,while group C was infused with saline instead.Blood glucose,plasma concentration of TXB2 and 6-keto-PGF1α were assessed before and after intubation as well as after extubation,and glucose coefficient of variation(GluCV) was calculated.Results The concentrations of TXB2 and 6-keto-PGF1α were increased after intubation and extubation in both groups(P0.05).The level of TXB2 was lower while 6-keto-PGF1α was higher in group D than those in group C(P0.05).The ratio of TXB2 to 6-keto-PGF1α was markedly increased in group C and was significantly higher than that of group D(P0.05).The GluCV of group D was significantly smaller than that of group C.Conclusion Dexmedetomidine can markedly suppress the stress response induced by endotracheal intubation and surgical stimuli,can effectively control the perioperative blood glucose fluctuation in patients with high blood glucose and coronary heart disease,and can improve the balance between TXA2 and PGI2." @default.
- W2383703078 created "2016-06-24" @default.
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- W2383703078 date "2012-01-01" @default.
- W2383703078 modified "2023-09-26" @default.
- W2383703078 title "The effect of dexmedetomidine on perioperative blood glucose variability and thromboxane A_2/epoprostenol balance in patients with high blood glucose and coronary heart disease" @default.
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