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- W2383710130 abstract "Objective To examine the methylation status of the RASSF1A promoter region and its mRNA expression levels in renal cell carcinoma.Method DNA obtained from 19 cases of renal cell carcinoma with adjacent tumor kidney tissue were treated by bisulfite.The methylation status of RASSF1A was evaluated by Methylation specific PCR(MSP) and the expression level of RASSF1A mRNA was evaluated by QPCR.Result 10 cases were found to have a decreased in the expression of RASSF1A mRNA and an increased in methylation in the promoter region.The reduced in mRNA expression is negatively correlated with the increased in methylation(r =-0.8734,P0.01).Conclusion Hypermethylation was detected in the RASSF1A promoter region in renal cell carcinoma." @default.
- W2383710130 created "2016-06-24" @default.
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- W2383710130 date "2008-01-01" @default.
- W2383710130 modified "2023-09-24" @default.
- W2383710130 title "Methylation of CpG Region in Promoter Region of RASSF1A in Renal Cell Carcinoma" @default.
- W2383710130 hasPublicationYear "2008" @default.
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