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- W2383726907 abstract "AIM: To investigate the microsatellite alteration (MA) at chromosome 6q in the early diagnosis of bladder tumor and to study whether the loss of heterozygosity (LOH) at 6q is related to the development of bladder tumor. METHODS: D6S404 and D6434 microsatellite markers near 6q21 were tested by PCR SSLP stain method in both the urine sediment DNA and tumor DNA from 31 cases of bladder tumor. RESULTS: Among the 31 cases of bladder tumor, 64.5% of the tumor tissue DNA and 58 1% of the urine sediments DNA showed MA, while the 10 non bladder tumor cases had no changes at either of the two loci. The result was not associated with the grade or stage of the tumor. LOH was detected in tumor tissues on site for D6S404 (35 5%) and D6S434 (22 6%). CONCLUSION: Microsatellite analysis of urine sediments is of significance in the early diagnosis of bladder tumor and there may be some tumor suppressor gene relevant to the development of bladder tumor near 6q21." @default.
- W2383726907 created "2016-06-24" @default.
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- W2383726907 date "2003-01-01" @default.
- W2383726907 modified "2023-09-23" @default.
- W2383726907 title "Investigation on microsatellite alteration at chromosome 6q of urine sediment in bladder tumor" @default.
- W2383726907 hasPublicationYear "2003" @default.
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