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- W2383729597 abstract "By transfering N-3 fatty acid desaturase gene to pork to make N-6 polyunsaturated fatty acids into N-3 polyunsaturated fatty acids, a new way to supplement N-3 polyunsaturated fatty acid can be found. Sub- chronic toxicity effect of the genetically modified meat which containing N-3 fatty acid desaturase gene on pigs can be observed. One hundred and forty, 4~5 weeks old Sprague Dawley rats(Rattus norvegicus) were ran- domly divided into 7 groups according to the weight and gender, given a nutritionally balanced purified diet containing 3.75%,7.50% and 15.00%transgenic or conventional meat for 90 d. AIN-93 normal diet was used as an additional control group. Body weight, food consumption, haematological parameter and clinical bio- chemistry parameter were observed during the experiment period. At the end, the rats were sacrificed and or- gan weight measurement analysis and pathological examnation were performed. There were no significant dif- ferences of some indices of body weight, food utilization, hematology, clinical biochemistry, organ index and organ pathological examnation in transgenic meat group, compared to parental meat group and AIN- 93 group. There was no adequate evidence to indicate the subchronic toxicity and adverse effects for transgenic meat which containing N-3 fatty acid desaturase gene on rats. This also provides reference data to assess comprehensive safety of N-3 fatty acid desaturase gene transgenic technology." @default.
- W2383729597 created "2016-06-24" @default.
- W2383729597 creator A5072053652 @default.
- W2383729597 date "2013-01-01" @default.
- W2383729597 modified "2023-09-25" @default.
- W2383729597 title "Subchronic Toxicity Study in Sprague- Dawley Rats (Rattus norvegicus) of Genetically Modified Meat Expressing N-3 Fatty Acid Desaturase Gene" @default.
- W2383729597 hasPublicationYear "2013" @default.
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