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- W2383732181 abstract "Endothelial dysfunction,a recognized indicator of cardiovascular risk,is an early event in the atherosclerosis process.Statins have been shown to improve endothelial-dependent vasomotion,which is mediated through a reduction in lipid levels.The cholesterol-independent or effects of statins involve the increase of endothelial nitric oxide synthasization,decrease of oxidative stress and inflammation,decrease leukocyte adhesion and transmigration,and promote re-endothelialization after arterial injury.This review will emphasize the molecular mechanisms underlying the effects of statins on endothelial function,particularly the inhibition of small GTP-binding proteins,Rho,Ras and Rac,which seem to be playing an important role in mediating the pleiotropic effects of statins." @default.
- W2383732181 created "2016-06-24" @default.
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- W2383732181 date "2008-01-01" @default.
- W2383732181 modified "2023-09-26" @default.
- W2383732181 title "Pleiotropic Effects of Statins on Endothelial Dysfunction" @default.
- W2383732181 hasPublicationYear "2008" @default.
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