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- W2383755909 abstract "Objective To investigate the aetiology and the pathogenesis of enterocolitis complicated with Hirschsprung's disease.Methods Mucosal immune defence of colonic specimens from patients of Hirschsprung's disease was studied by immunohistochemical and radioimmunological methods.Results Compared to the 8 patients of Hirschsprung's disease without enterocolitis, five cases with Hirschsprung's disease and enterocolitis had markedly deficient transfer of IgA across distribution of CD4 and CD8 positive cells in lamina propria.Conclusions Patients of Hirschsprung's disease complicated with enterocolitis have compromised local mucosal immune defence. Stasis of fecal content,multiplication of bacteria and endotoxin production further damage the mucosa, leading to deterioration of mucosal immune mechanism. This may be a possible complex mechanism of Hirschsprung's disease and enterocolitis." @default.
- W2383755909 created "2016-06-24" @default.
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- W2383755909 date "1999-01-01" @default.
- W2383755909 modified "2023-09-23" @default.
- W2383755909 title "Mucosal Immune Defence in Enterocolitis Complicating with Hirschsprung's Disease" @default.
- W2383755909 hasPublicationYear "1999" @default.
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