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- W2383760260 abstract "Aim To observe the effects of recombinant human endostatin(rhEndostatin) on cell cycle and the expression of proliferating cell nuclear antigen(PCNA) in fibroblast-like synoviocytes in rats with adjuvant arthritis(AA),and to explore the molecular mechanisms of the inhibitory effect of rhEndostatin on proliferation of fibroblast-like synoviocytes(FLS) in AA rats.Methods Adjuvant arthritis was induced by Freund′s complete adjuvant in rats.Flow cytometry was applied to measure the effects of rhEndostatin on the cell cycle in AA FLS.The effect of rhEndostatin on the expression of PCNA mRNA and protein in synovial tissue in AA rats was examined quantitatively by real-time fluorescent quantitative PCR and Western blot assays,respectively.Results The percentage of cells in G1 phase in AA FLS decreased significantly(P0.01),and the rate of cells in S and G2/M phase increased significantly(P0.01),compared with that in normal controls.The expression levels of PCNA mRNA and protein in AA synovial tissue were significantly higher than those in normal samples(P0.05,P0.01).However,the percentage of cells in G1 phase in FLS treated with rhEndostatin increased significantly(P0.01),and the rate of cells in S and G2/M phase decreased significantly(P0.01),compared with that in AA controls.The expression levels of PCNA mRNA and protein in synovial tissue treated with rhEndostatin were significantly lower than those in AA group(P0.01).Conclusion Recombinant human endostatin causes cell cycle arrest in G1 in AA FLS,which may be involved in its inhibitory effect on PCNA expression in AA FLS." @default.
- W2383760260 created "2016-06-24" @default.
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- W2383760260 date "2009-01-01" @default.
- W2383760260 modified "2023-09-25" @default.
- W2383760260 title "Effects of recombinant human endostatin on cell cycle and PCNA expression in fibroblast-like synoviocytes in rats with adjuvant arthritis" @default.
- W2383760260 hasPublicationYear "2009" @default.
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