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- W2383767488 abstract "Objective To evaluate the possible effects of tamoxifen combining with chemotherapy in human colorectal carcinoma cell lines SW480、HT29. Methods Tetrazolium(MTT) assay was used and the inhibition effects were compared in cultures of SW480 and HT29 with tamoxifen alone and with tamoxifen combining with chemotherapy, and observed the possible mechanism of whether tamoxifen could increase the chemosensitization or not by detected mdrl coded P-gp.Results Tamoxifen at concentration of 5 μmol/L increased the chemosensitivity of 5-FU and MTX by 1.5976 to 1.6456-fold in SW480 cell line.Tamoxifen at concentration of 10 μmol/L increased the chemosensitivity of 5-FU、MMC、MTX、ADM by 4.1524、2.0244、4.7833 to 2.2323-fold respectively in SW480 cell line and increased 4.7713、4.7865、4.2557、4.4713-fold in HT29 cell line(P0.05) respectively. Chemotherapy durgs caused the cultural SW480 and HT29 cell lines in vitro to produce drug resistence (P1,P20.05) , while Tmoxifen could significantly reverse (P3,P40.05).Conclusion In vitro,Tamoxifen can enhance the chemosensitivity of 5-FU、MMC、MTX、ADM at different concentrations and its possible mechanism is that Tamoxifen inhibits the increase of mdr1 mode P-gp." @default.
- W2383767488 created "2016-06-24" @default.
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- W2383767488 date "2003-01-01" @default.
- W2383767488 modified "2023-09-28" @default.
- W2383767488 title "The effects of tamoxifen combining with chemotherapy in human colorectal carcinoma cell line SW480, HT29" @default.
- W2383767488 hasPublicationYear "2003" @default.
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