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- W2383794499 abstract "Objective To screen efficient anti-influenza A(H5N1)medicine with low toxicity.Methods Normal control group,virus control group and test group were included in this study.The inhibitory effect and cytotoxicity of modified amantadine(NAM)on H5N1 virus and MDCK cells were detected by MTT and cytopatric effect(CPE)assay,respectively.The therapy index(TI)and 50% cell-inhibitory concentration(IC50)were calculated.The mice infected with H5N1 virus were administered with NAM.The death rate,survival rate,death protection rate and prolong survival rate were calculated.Results The maximal no cytoxicity concentration and 50% cytoxicity concentration of NAM on MDCK cells were 235.09 mg·L-1 and 1582.78 mg·L-1,respectively.The IC50 and TI of NAM on H5N1 virus were 15.32 mg·L-1 and 103.31,respectively.The death rate(12.5%)in NAM 100 mg·kg-1 group was significantly lower than that in virus control group(87.5%)(P0.05),the mean survival days(13.38 d)was significantly higher than that in virus control group(9.63 d)(P0.05),both inhibitory rate of pneumonia(99.15%)and prolongation survival rate(26.79%)were higher than those in amantadine group(69.18% and 13.39%)(P0.05).Conclusion NAM has better antivirus activity and lower toxicity,compared with amantadine in vitro.NAM can significantly decrease mortality,increase average survival days and prolongation survival rate in vivo." @default.
- W2383794499 created "2016-06-24" @default.
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- W2383794499 date "2007-01-01" @default.
- W2383794499 modified "2023-09-23" @default.
- W2383794499 title "Inhibitory effect of modified amantadine on avian influenza (H_5N_1) virus" @default.
- W2383794499 hasPublicationYear "2007" @default.
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