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- W2383810356 abstract "Objective:To investigate the effects of IP10(IFN-γ inducible protein 10,CXCL10) on anti-tumor immune response and to explore its mechanisms involved in.Methods:A mammary carcinoma cell line 4T1 was transfected with pcDNA3-IP10(IP10-4T1) by electrophoration and positive clones were screened in the presence of G418.Growth kinetics of IP10-4T1 cells was observed in vitro and in vivo.Survival rate among the animals was determined by daily assessment.Proliferation activity of lymphocytes was analyzed with()~3H-TdR incorporation.The phenotypes of lymphocytes isolated from tumors by ficoll density gradient centrifugation were assayed by flow cytometry.Results:The growth rate of IP10-4T1 cells was similar with that of parental 4T1 cells and neo-vector transfected 4T1 cells in vitro.Growth of the tumors formed by IP10-4T1 cells was inhibited in vivo.Compared to those of controls,the size and the weight of the tumors formed by IP10-4T1 cells decreased significantly 35 days post tumor transplantation(P0.05).And the survival rate of IP10-4T1 tumor-bearing mice increased dramatically.In contrast to the controls,the splenocytes from mice inoculated with IP10-4T1 cells proliferated vigorously after stimulated with specific antigen in vitro(P0.05).Accumulated CXCR3~+T cells were detected in the tumors formed by IP10-4T1 cells.After stimulated with specific antigen,proliferation activity of the infiltrated lymphocytes isolated from IP10-4T1 tumors was much stronger than that of controls(P0.05).Conclusion:IP10 plays a role in anti-tumor immunity by enhancing cellular immune response and promoting infiltration and proliferation of lymphocytes in tumors." @default.
- W2383810356 created "2016-06-24" @default.
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- W2383810356 date "2006-01-01" @default.
- W2383810356 modified "2023-09-25" @default.
- W2383810356 title "IP10 enhances anti-tumor immunity and its mechanisms" @default.
- W2383810356 hasPublicationYear "2006" @default.
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