Matches in SemOpenAlex for { <https://semopenalex.org/work/W2383815583> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2383815583 abstract "Purpose:To study on the mechanism of methotrexate (MTX )resistance, so that MTX could be used in variety of malignant lymphomas,in order to reduce side effects of chemotherapy and enhance its effecacy and give the patients a better quality of life for lone term survivors.Methods:MTT drug sensitivity test was used to evaluate the MTX sensitivity in Sup m2,Namalwa and Namalwa 12 cell lines. RT PCR and 3H MTX with HPLC were used to examine the degree of dihydrofolate reductase (DHFR) mRNA expression,reduced folate carrier (RFC) function and polyglutamate MTX ( MTXPG). Results:The orders for MTX sensitivity of various cell lines were observed as follows: Sup m2Namalwa Namalwa12. This difference was not the result from differences in RFC function, but from the quantity of MTXPG. Comparing with Namalwa cell line, Sup m2 cell line had the ability not only of producing more MTXPG, but also reaching saturation early. Gradually increased expression of DHFR mRNA was the direct cause of the formation of MTX resistance in Namalwa/MTX cell line. Conclusions:Diminished RFC function, dysformation of MTXPG and overexpresion of DHFR mRNA develop MTX resistance in Namalwa 12 cell line. Patient with large cell anaplastic lymphoma possess high sensitivity to MTX, suggesting that the dosage of MTX may be scaled down, the time of usage may also be shortened." @default.
- W2383815583 created "2016-06-24" @default.
- W2383815583 creator A5014236405 @default.
- W2383815583 date "2001-01-01" @default.
- W2383815583 modified "2023-09-25" @default.
- W2383815583 title "Resistance and its mechanism of methotrexate against malignant lymphoma cell lines" @default.
- W2383815583 hasPublicationYear "2001" @default.
- W2383815583 type Work @default.
- W2383815583 sameAs 2383815583 @default.
- W2383815583 citedByCount "0" @default.
- W2383815583 crossrefType "journal-article" @default.
- W2383815583 hasAuthorship W2383815583A5014236405 @default.
- W2383815583 hasConcept C114851261 @default.
- W2383815583 hasConcept C126322002 @default.
- W2383815583 hasConcept C185592680 @default.
- W2383815583 hasConcept C203014093 @default.
- W2383815583 hasConcept C2776694085 @default.
- W2383815583 hasConcept C2778397455 @default.
- W2383815583 hasConcept C2779338263 @default.
- W2383815583 hasConcept C2780783641 @default.
- W2383815583 hasConcept C2781059491 @default.
- W2383815583 hasConcept C2781320022 @default.
- W2383815583 hasConcept C2781382166 @default.
- W2383815583 hasConcept C502942594 @default.
- W2383815583 hasConcept C54355233 @default.
- W2383815583 hasConcept C55493867 @default.
- W2383815583 hasConcept C62112901 @default.
- W2383815583 hasConcept C71924100 @default.
- W2383815583 hasConcept C81885089 @default.
- W2383815583 hasConcept C86803240 @default.
- W2383815583 hasConcept C98274493 @default.
- W2383815583 hasConceptScore W2383815583C114851261 @default.
- W2383815583 hasConceptScore W2383815583C126322002 @default.
- W2383815583 hasConceptScore W2383815583C185592680 @default.
- W2383815583 hasConceptScore W2383815583C203014093 @default.
- W2383815583 hasConceptScore W2383815583C2776694085 @default.
- W2383815583 hasConceptScore W2383815583C2778397455 @default.
- W2383815583 hasConceptScore W2383815583C2779338263 @default.
- W2383815583 hasConceptScore W2383815583C2780783641 @default.
- W2383815583 hasConceptScore W2383815583C2781059491 @default.
- W2383815583 hasConceptScore W2383815583C2781320022 @default.
- W2383815583 hasConceptScore W2383815583C2781382166 @default.
- W2383815583 hasConceptScore W2383815583C502942594 @default.
- W2383815583 hasConceptScore W2383815583C54355233 @default.
- W2383815583 hasConceptScore W2383815583C55493867 @default.
- W2383815583 hasConceptScore W2383815583C62112901 @default.
- W2383815583 hasConceptScore W2383815583C71924100 @default.
- W2383815583 hasConceptScore W2383815583C81885089 @default.
- W2383815583 hasConceptScore W2383815583C86803240 @default.
- W2383815583 hasConceptScore W2383815583C98274493 @default.
- W2383815583 hasLocation W23838155831 @default.
- W2383815583 hasOpenAccess W2383815583 @default.
- W2383815583 hasPrimaryLocation W23838155831 @default.
- W2383815583 hasRelatedWork W1524793778 @default.
- W2383815583 hasRelatedWork W2000938027 @default.
- W2383815583 hasRelatedWork W2003171499 @default.
- W2383815583 hasRelatedWork W2004072843 @default.
- W2383815583 hasRelatedWork W2006848151 @default.
- W2383815583 hasRelatedWork W2012859679 @default.
- W2383815583 hasRelatedWork W2014756272 @default.
- W2383815583 hasRelatedWork W2021510630 @default.
- W2383815583 hasRelatedWork W203459641 @default.
- W2383815583 hasRelatedWork W2056650132 @default.
- W2383815583 hasRelatedWork W2072203896 @default.
- W2383815583 hasRelatedWork W2086839631 @default.
- W2383815583 hasRelatedWork W2087986635 @default.
- W2383815583 hasRelatedWork W2091068832 @default.
- W2383815583 hasRelatedWork W2126722770 @default.
- W2383815583 hasRelatedWork W2339408202 @default.
- W2383815583 hasRelatedWork W2403952550 @default.
- W2383815583 hasRelatedWork W2409916698 @default.
- W2383815583 hasRelatedWork W2472808267 @default.
- W2383815583 hasRelatedWork W2991332522 @default.
- W2383815583 isParatext "false" @default.
- W2383815583 isRetracted "false" @default.
- W2383815583 magId "2383815583" @default.
- W2383815583 workType "article" @default.