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- W2383822145 abstract "Objective To compare the combined and respective effects of ginsenoside Rg3 and IFN-α on murine hepatic fibrosis due to Schistosoma japonicum.Methods 56 adult male IcR mice were randomized into 5 groups: A,B,C,D and E group.Each group had 12 mice except for group A with 8.Group A was a normal control group.Mice in group B,C,D and E were infected with 18～22 cercariae of S.japonicum in one day via abdominal skin puncture respectively.10 weeks later,the infected mice in the group B,C,D and E were treated with PZQ in a single oral dose to kill adult worms.Then,from the next day,mice in group B were treated with Ginsenoside Rg3 combined with IFN-α,mice in group C and D were treated with Ginsenoside Rg3 and IFN-α,respectively;mice in group E had no treatment,once a day for 8weeks.After 8-week treatment,liver tissue samples of the paraffin-embedded sections were made into serial 4 μm slices and were stained with hematoxylin eosin(HE)and van gieson(VG)to observe the histological changes,measure percentages of collagen fiber content in the liver tissue using graphic computing,and assess the scores through the semi-quantitative score scheme(SSS)or chronic hepatitis and liver fibrosis.Results After 8 weeks of treatment,mice in the B,C andD treatment groups had an enlarged liver.The liver was firm and dark brown in color,but the degree of fiber hyperplasia and inflammatory infiltration were mitigated compared to the group E.The mean percentages of the collagen content in the groupB,C and D,were lower than those of the group E(P0.05).Meanwhile,the SSS scores of the group B,C and D were lower 2 scores at least than the group E,respectively(P0.05).Conclusions Combined and respective ginsenoside Rg3 and IFN-α have similar anti-hepatofibrosis effects on schistosomiasis-induced hepatic fibrosis in mice after treatment of PZQ.However,in terms of the effects of anti-hepatofibrosis,there are no statistically significant differences among these three treatment groups.The effect of Rg3 combined with IFN-α on anti-hepatofibrosis is not better than that of either one singly." @default.
- W2383822145 created "2016-06-24" @default.
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- W2383822145 date "2012-01-01" @default.
- W2383822145 modified "2023-09-25" @default.
- W2383822145 title "Comparison of Combined and Respective Effects of Ginsenoside Rg3 and Interferon-α on Schistosomiasis Japonica Caused Hepatic Fibrosis in Mice" @default.
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