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- W2383822575 abstract "Objective To investigate the different expression of Toll-like receptor2,4(TLR2,4)mRNA on splenic macrophage(Mφ) in hypersplenism due to portal hypertension(PH),providing the evidence for dis-cussing the effects of TLR in pathogenesis of hypersplenism.Methods 12 patients with hypersplenism due to PH and 4 patients with traumatic rupture of spleen were regarded as hypersplenia and control group respectively.The expressions of TLR2,4 were detected by real time-PCR.The results of two groups were compared.Results As compared to control group,the expression of TLR2,4 mRNA were increased significantly(TLR2:2.29±0.55 vs 1.06±0.53,P 0.05;TLR4:2.32±0.41 vs 1.01±0.14,P0.01).Conclusion The expression of TLR2,4mRNA increased significantly,consistent with the result of protein expression.It has been further supported thatendotoxemia→activation of TLRs→increase of phagocytosis of splenic Mφ→hypersplenism,this may be one of the mechanism of hypersplenism due to PH." @default.
- W2383822575 created "2016-06-24" @default.
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- W2383822575 date "2008-01-01" @default.
- W2383822575 modified "2023-09-23" @default.
- W2383822575 title "Expression of Toll-like receptor 2,4 mRNA of splenic macrophage in hypersplenism due to portal hypertension" @default.
- W2383822575 hasPublicationYear "2008" @default.
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