Matches in SemOpenAlex for { <https://semopenalex.org/work/W2383829573> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2383829573 endingPage "8" @default.
- W2383829573 startingPage "115" @default.
- W2383829573 abstract "The major obstacle in pig to human transplantation is acute and hyperacute rejection (HAR) triggered mainly by alpha-galactosyl residues(alpha-Gal) in donor. Since the inbred-line Banna pig(IBNP) and Wuzhishan pig (IWZSP) are highly inbred and may be the potential donor for xenotransplantation, it is important to investigate the reaction between human serum and inbred-line pig tissues as well as the distribution of alpha-Gal in these tissues.Samples from heart, liver, spleen, lung, kidney, pancreas, small intestine, thymus, skin, lymph node and blood vessels at all levels were collected from four 8 to 11-month-old male IBNPs and one IWZSP. Affinity-immunohistochemistry assays were conducted following routine procedures on paraffin sections with normal human sera of blood type A, B, O, AB and BSI-B4(alpha-Gal specific binding lectin) as the primary antibodies or affinity reagents. Sections digested by alpha-galactosidase were also examined as control.Parallel results were obtained from these pig tissues stained against human sera and BSI-B4. There was no significant difference both in the antigens recognized by sera of different blood types or BSI-B4 and in the distribution of alpha-Gal. The strongest alpha-Gal positive staining was appeared in vascular endothelial cells at all levels and partial parenchyma cells. However, tissues of cartilage, peripheral nerve and muscle were negative. After digested by alpha-Galactosidase, all samples were negative against BSI-B4 and human sera except few positions that showed different staining.The distribution of target antigen is similar in various tissues of the two kinds of pigs. Though alpha-Gal is the major xenoantigen in IBNP and IWZSP, there may be some unknown antigens related to pig to human transplantation. Possibly the level and distribution of antigen expression in pig tissues are not the first affair to be considered, and these pigs should be genetically modified in order to eliminate rejection in pig to human xenotransplantation." @default.
- W2383829573 created "2016-06-24" @default.
- W2383829573 creator A5040721399 @default.
- W2383829573 creator A5062493199 @default.
- W2383829573 creator A5080066400 @default.
- W2383829573 date "2000-03-01" @default.
- W2383829573 modified "2023-10-18" @default.
- W2383829573 title "[The xenoantigenicity of Chinese inbred-line pigs]." @default.
- W2383829573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11778189" @default.
- W2383829573 hasPublicationYear "2000" @default.
- W2383829573 type Work @default.
- W2383829573 sameAs 2383829573 @default.
- W2383829573 citedByCount "0" @default.
- W2383829573 crossrefType "journal-article" @default.
- W2383829573 hasAuthorship W2383829573A5040721399 @default.
- W2383829573 hasAuthorship W2383829573A5062493199 @default.
- W2383829573 hasAuthorship W2383829573A5080066400 @default.
- W2383829573 hasConcept C126322002 @default.
- W2383829573 hasConcept C142724271 @default.
- W2383829573 hasConcept C153911025 @default.
- W2383829573 hasConcept C159654299 @default.
- W2383829573 hasConcept C203014093 @default.
- W2383829573 hasConcept C204232928 @default.
- W2383829573 hasConcept C2778442404 @default.
- W2383829573 hasConcept C2778527173 @default.
- W2383829573 hasConcept C2780931953 @default.
- W2383829573 hasConcept C2911091166 @default.
- W2383829573 hasConcept C54355233 @default.
- W2383829573 hasConcept C71924100 @default.
- W2383829573 hasConcept C86803240 @default.
- W2383829573 hasConceptScore W2383829573C126322002 @default.
- W2383829573 hasConceptScore W2383829573C142724271 @default.
- W2383829573 hasConceptScore W2383829573C153911025 @default.
- W2383829573 hasConceptScore W2383829573C159654299 @default.
- W2383829573 hasConceptScore W2383829573C203014093 @default.
- W2383829573 hasConceptScore W2383829573C204232928 @default.
- W2383829573 hasConceptScore W2383829573C2778442404 @default.
- W2383829573 hasConceptScore W2383829573C2778527173 @default.
- W2383829573 hasConceptScore W2383829573C2780931953 @default.
- W2383829573 hasConceptScore W2383829573C2911091166 @default.
- W2383829573 hasConceptScore W2383829573C54355233 @default.
- W2383829573 hasConceptScore W2383829573C71924100 @default.
- W2383829573 hasConceptScore W2383829573C86803240 @default.
- W2383829573 hasIssue "2" @default.
- W2383829573 hasLocation W23838295731 @default.
- W2383829573 hasOpenAccess W2383829573 @default.
- W2383829573 hasPrimaryLocation W23838295731 @default.
- W2383829573 hasRelatedWork W1992478450 @default.
- W2383829573 hasRelatedWork W1996368387 @default.
- W2383829573 hasRelatedWork W2013745628 @default.
- W2383829573 hasRelatedWork W2035464821 @default.
- W2383829573 hasRelatedWork W2072194757 @default.
- W2383829573 hasRelatedWork W2099754504 @default.
- W2383829573 hasRelatedWork W2367721208 @default.
- W2383829573 hasRelatedWork W2431436483 @default.
- W2383829573 hasRelatedWork W2738867127 @default.
- W2383829573 hasRelatedWork W88270181 @default.
- W2383829573 hasVolume "14" @default.
- W2383829573 isParatext "false" @default.
- W2383829573 isRetracted "false" @default.
- W2383829573 magId "2383829573" @default.
- W2383829573 workType "article" @default.