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- W2383830575 abstract "OBJECTIVE To explore the protective effects of ginkgo biloba extract(EGb) on the injuries of renal function induced by cisplatin(DDP) in rats.METHODS The model of renal injury in rats was induced by a single intraperitoneal injection of DDP at the dose of 7.5 mg·kg-1.The rats were pretreated with EGb(50 or 100 mg·kg-1) once a day for 5 days and then single intraperitoneal injected DDP 72 h before the experiment.RESULTS DDP significantly increased the serum levels of BUN and Cr,and the content of malonadialdihyde(MDA) in renal cortex,and inhibited the activity of superoxide dismutase(SOD) and paraoxoinase(PON1).EGb markedly decreased the serum levels of BUN and Cr,the renal cortex content of MDA,and elevated the activity of SOD and PON1 in the rats pretreated with DDP.CONCLUSION The results suggest that a single intraperitoneal injection of DDP caused renal injuries in the rats,and the protective effect of EGb on renal function is related to reduction of lipid peroxidation concentration by inhibition of PON1 activity." @default.
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- W2383830575 date "2008-01-01" @default.
- W2383830575 modified "2023-09-23" @default.
- W2383830575 title "Protective effects of ginkgo biloba extract on renal injuries induced by cisplatin" @default.
- W2383830575 hasPublicationYear "2008" @default.
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