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- W2383832153 abstract "Objective To analyze the expression of VEGFR-1 and VEGFR-2 in samples for patients with medullary thyroid carcinoma(MTC) and to explore their correlation with clinical parameters.Methods Parafinembedded samples from 24 patients with MTC(aged 44.9 ±14.1 years) were evaluated for VEGFR-1 and VEGFR-2 expression by immunohistochemistry.Clinical data were retrospectively reviewed.Results Eight patients(33.3%) had hereditary MTC.Six of them had multiple endocrine neoplasia(MEN)-2A and two MEN-2B.VEGFR-1 expression was detected in 91.7%(22/24) of MTC samples,VEGFR-2 in 87.5%(21/24).Age had positive correlation with VEGFR-2(r=0.609,P=0.002).There was no correlation between VEGFR-2 and tumor stage(tumor node metastasis),tumor size,the relative decrease in serum CEA,or calcitonin before surgery and after.Nevertheless,VEGFR-1 was found to be inversely correlated with tumor node metastasis(r=-0.660,P=0.0005),and positively with the relative decrease in serum CEA and calcitonin before surgery and after(CEA: r=0.869;calcitonin:r=0.849,P0.0001).We also observed a positive correlation between VEGFR-1 signal intensity and cure of disease(r=0.523,P=0.009).VEGFR-2 had no correlation with disease outcome through a follow-up period of 5.0 ±2.8 years(P =0.407).No difference were found for the staining intensity of VEGFR-1 and VEGFR-2 between hereditary and sporadic MTC(P0.05).Conclusions The VEGFR-1 and VEGFR-2 overexpress in MTC patients and may be implicated in tumor progression." @default.
- W2383832153 created "2016-06-24" @default.
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- W2383832153 date "2013-01-01" @default.
- W2383832153 modified "2023-09-23" @default.
- W2383832153 title "High expression of VEGFR-1 and VEGFR-2 in medullary thyroid carcinoma" @default.
- W2383832153 hasPublicationYear "2013" @default.
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