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- W2383838773 abstract "Aim To investigate the effect of protein kinase C inhibitor on expression of intercellular adhesion molecule-1 protein and mRNA in smoking rats.Methods The expression of intercellular adhesion molecule-1 protein and mRNA were abserved by immunohistochemistry and in situ hybrizition.18 non-infarcted rats were randomly divided into three groups including 6 non-smoking rats,6 no medicine treated smoking rats and 6 protein kinase C inhibitor treated smoking rats.48 infarcted rats were randomly divided into two groups including 24 no medicine treated rats and 24 protein kinase C inhibitor treated rats.2 hours,6 hours,12 hours or 24 hours after infarction the medicine were given,6 rats in each time points.Results Compared with no medicine groups,the expression of intercellular adhesion molecule-1 and intercellular adhesion molecule-1 mRNA were decreased with corresponding indentical time points in protein kinase C inhibitor groups,which showed statistical difference(P0.05).Conclusions Protein kinase C inhibitor could reduce the expression of intercellular adhesion molecule-1 and intercellular adhesion molecule-1 mRNA in smoking rats cerebrovascularendothelial cells,the medicine were given more early,more effect will be produced." @default.
- W2383838773 created "2016-06-24" @default.
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- W2383838773 date "2007-01-01" @default.
- W2383838773 modified "2023-09-25" @default.
- W2383838773 title "Effects of Protein Kinase C Inhibitor on the Expression of Intercellular Adhesion Molecule-1 Protein and mRNA on Cerebrovascularendothelial Cells in Smoking Rats" @default.
- W2383838773 hasPublicationYear "2007" @default.
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