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- W2383841093 abstract "OBJECTIVE:To study the effects of ethanol extract of Scorpion(EES) on mRNA expression of hippocampus GFAP in rats with chronic epilepsia.METHODS:Rats were injected with lithium chloride(Licl) 127 mg·kg-1(3 mmol·kg-1) and atropine sulfate 1 mg·kg-1 for 18～24 h intraperitoneally on the first day.30 min later,they were given pilocarpine(Pilo) 30 mg·kg-1 intraperitoneally to induce chronic epilepsia model.Model rats were randomly divided into normal control group(isovolumic saline),model group(isovolumic saline),valproic acid group(120 mg·kg-1),EES low-dose(290 mg·kg-1),medium-dose(580 mg·kg-1)and high-dose(1 160 mg·kg-1) groups.The degree of chronic epilepsia attack in rats was observed,and the mRNA expression of hippocampus GFAP was observed by RT-PCR at 6 hour and 1 day,3 day,7 day,14 day and 30 day after status epilepticus.RESULTS:Compared with model group,epileptic seizures grading was significantly changed in EES high-dose group and EES medium dose group.3 days after modeling,mRNA expression of hippocampus GFAP in rats was up-regulated significantly,reached to the peak 7 days later,and then declined gradually,which was still higher than normal control group.Compared with model group,GFAP mRNA contents had declined significantly in EES high-dose and medium-dose groups after 7 days of treatment(P0.05).CONCLUSION:High-dose and medium-dose of EES can reduce the mRNA expression of hippocampus GFAP in rats with chronic epilepsia,which is an important anti-epileptic mechanism." @default.
- W2383841093 created "2016-06-24" @default.
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- W2383841093 date "2012-01-01" @default.
- W2383841093 modified "2023-09-25" @default.
- W2383841093 title "Effects of Ethanol Extract of Scorpion on the mRNA Expression of Hippocampus GFAP in Rats with Chronic Epilepsia" @default.
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