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- W2383851896 abstract "Objective To observe the effects of rosiglitazone on expression of matrix metalloproteinase (MMP)-2 and its inhibitor TIMP-2 after balloon endothelial denudation of iliac artery in rabbits and to investigate the mechanism of rosiglitazone in prevention and treatment of restenosis. Methods Forty male New Zealand white rabbits were randomly divided into control (normal diet), model (hyper-cholesterol diet plus balloon endothelial denudation), rosuvastatin calciumtablets (balloon endothelial denudation plus hyper-cholesterol diet supplemented with rosuvastatin calciumtablets) and rosiglitazone groups (balloon endothelial denudation plus hyper-cholesterol diet supplemented with rosiglitazone). After 12 w, serum lipids levels were measured. The local iliac arteries were sectioned for analysis of pathological morphology and were stained for MMP-2 and TIMP-2 immunohistochemistrical analysis.Results ①The level of serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholestorol (LDL-C) in rosiglitazone group were significantly lower than those in model group. ②The intimal thickness (IT), intimal area (IA), IT/MT ratio and IA/MA ratio of rosiglitazone group were significantly lower than those in model group. ③The expression of MMP-2 in rosiglitazone group was significantly lowered than that in model group, but there was no significant changes in TIMP-2 expression between two groups. Conclusions Rosiglitazone could efficiently inhibit intimal proliferation during the restenosis after balloon, the mechanism of which may be related to the imbalance of MMP-2/TIMP-2." @default.
- W2383851896 created "2016-06-24" @default.
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- W2383851896 date "2008-01-01" @default.
- W2383851896 modified "2023-09-25" @default.
- W2383851896 title "Effects of rosiglitazone on the expression of matrix metalloproteinase-2 and its inhibitor after balloon endothelial denudation of iliac artery in rabbits" @default.
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