Matches in SemOpenAlex for { <https://semopenalex.org/work/W2383854062> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2383854062 abstract "Objective To investigate the application of functionalized carbon nanotubes as a new carrier in lymphatic chemotherapy for pancreatic cancer.Methods The multi-walled carbon nanotubes were functionalized(aminated).Then transmission electron microscopy(TEM) was used to observe the entrance of aminated carbon nanotubes into human pancreatic cancer cell line BxPC-3.The toxicity of aminated carbon nanotubes on BxPC-3 and the efficacy of carbon nanotubes carrying gemcitabine on cell growth were evaluated by 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide(MTT) assay.And lymph node mapping was used to evaluate pro-lymphatic properties of carbon nanotubes in rats.Results TEM revealed an increased dispersion of multi-walled carbon nanotubes,which passed through the cell membrane into BxPC-3 cells.MTT assay showed no significant difference among the efficacy of different concentrations of carbon nanotubes on BxPC-3 cell growth, while the carbon nanotubes carrying gemcitabine significantly inhibited cell growth,slightly higher than gemcitabine group(50.2%±5.0%vs.41.4%±6.6%,P0.05).After subcutaneous injection in the foot pad of rats, nanotubes were tracked in various lymphatic drainage pathways(black dyed lymph nodes) with widespread distribution(as far as renal hilum and para-aortic lymph nodes).Conclusion Functionalized carbon nanotubes are pro-lymphatic and competent of carrying drugs and targeting tumor cells,while the carrier itself shows no significant cell toxicity.Functionalized carbon nanotubes may be a novel safe drug delivery system in pancreatic lymphatic chemotherapy." @default.
- W2383854062 created "2016-06-24" @default.
- W2383854062 creator A5035064408 @default.
- W2383854062 date "2011-01-01" @default.
- W2383854062 modified "2023-09-28" @default.
- W2383854062 title "Preliminary applications of functionalized carbon nanotubes as drug carrier in lymphatic chemotherapy for pancreatic cancer" @default.
- W2383854062 hasPublicationYear "2011" @default.
- W2383854062 type Work @default.
- W2383854062 sameAs 2383854062 @default.
- W2383854062 citedByCount "0" @default.
- W2383854062 crossrefType "journal-article" @default.
- W2383854062 hasAuthorship W2383854062A5035064408 @default.
- W2383854062 hasConcept C121608353 @default.
- W2383854062 hasConcept C126322002 @default.
- W2383854062 hasConcept C142724271 @default.
- W2383854062 hasConcept C171250308 @default.
- W2383854062 hasConcept C181152851 @default.
- W2383854062 hasConcept C192562407 @default.
- W2383854062 hasConcept C2776694085 @default.
- W2383854062 hasConcept C2779720271 @default.
- W2383854062 hasConcept C2779820397 @default.
- W2383854062 hasConcept C2780210213 @default.
- W2383854062 hasConcept C2780258809 @default.
- W2383854062 hasConcept C2780849966 @default.
- W2383854062 hasConcept C502942594 @default.
- W2383854062 hasConcept C513720949 @default.
- W2383854062 hasConcept C71924100 @default.
- W2383854062 hasConceptScore W2383854062C121608353 @default.
- W2383854062 hasConceptScore W2383854062C126322002 @default.
- W2383854062 hasConceptScore W2383854062C142724271 @default.
- W2383854062 hasConceptScore W2383854062C171250308 @default.
- W2383854062 hasConceptScore W2383854062C181152851 @default.
- W2383854062 hasConceptScore W2383854062C192562407 @default.
- W2383854062 hasConceptScore W2383854062C2776694085 @default.
- W2383854062 hasConceptScore W2383854062C2779720271 @default.
- W2383854062 hasConceptScore W2383854062C2779820397 @default.
- W2383854062 hasConceptScore W2383854062C2780210213 @default.
- W2383854062 hasConceptScore W2383854062C2780258809 @default.
- W2383854062 hasConceptScore W2383854062C2780849966 @default.
- W2383854062 hasConceptScore W2383854062C502942594 @default.
- W2383854062 hasConceptScore W2383854062C513720949 @default.
- W2383854062 hasConceptScore W2383854062C71924100 @default.
- W2383854062 hasLocation W23838540621 @default.
- W2383854062 hasOpenAccess W2383854062 @default.
- W2383854062 hasPrimaryLocation W23838540621 @default.
- W2383854062 hasRelatedWork W1523071718 @default.
- W2383854062 hasRelatedWork W1672884051 @default.
- W2383854062 hasRelatedWork W1997205409 @default.
- W2383854062 hasRelatedWork W2045226967 @default.
- W2383854062 hasRelatedWork W2067614652 @default.
- W2383854062 hasRelatedWork W2068122786 @default.
- W2383854062 hasRelatedWork W2130410341 @default.
- W2383854062 hasRelatedWork W2153236217 @default.
- W2383854062 hasRelatedWork W2159547506 @default.
- W2383854062 hasRelatedWork W2169547498 @default.
- W2383854062 hasRelatedWork W2288884614 @default.
- W2383854062 hasRelatedWork W2409345144 @default.
- W2383854062 hasRelatedWork W2477864239 @default.
- W2383854062 hasRelatedWork W2589363852 @default.
- W2383854062 hasRelatedWork W2747711805 @default.
- W2383854062 hasRelatedWork W2988296040 @default.
- W2383854062 hasRelatedWork W3144849582 @default.
- W2383854062 hasRelatedWork W3145367079 @default.
- W2383854062 hasRelatedWork W3174953398 @default.
- W2383854062 hasRelatedWork W3203815782 @default.
- W2383854062 isParatext "false" @default.
- W2383854062 isRetracted "false" @default.
- W2383854062 magId "2383854062" @default.
- W2383854062 workType "article" @default.