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- W2383883947 abstract "Objective To investigate the effect of IL-2 and IL-8 in the immunopathogenesis of experimental allergic encephalomyelitis(EAE).Methods The animal models were established in guinea pigs by immunization with complete Freund adjuvant and myelin basic protein extracted from bovine brain.The level of IL-2 in EAE model was detected by biologic assay and the level of IL-8 in EAE was examined by sandwich-enzyme-linked immunosorbent assay(ELISA).Results The levels of IL-2 and IL-8 in EAE were 194 21±97 88 U/ml and 6 35±0 29 ng/ml respectively.The EAE models showed obviously higher levels of IL-2 and IL-8 than the normal control group( P 0 01; P 0 05).Conclusions IL-2 and IL-8 play an important role in the immunopathogenesis of EAE.These cytokines are involved in the development during the course of immunopathologic damage.The theory that cytokines are the essential molecular basis for pathogenesis of EAE has been demonstrated.This experiment had offered theoretical evidence for study of multiple sclerosis(MS) on pathogenesis and given the clues for searching new therapeutic approaches of MS. [" @default.
- W2383883947 created "2016-06-24" @default.
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- W2383883947 date "2000-01-01" @default.
- W2383883947 modified "2023-09-23" @default.
- W2383883947 title "Assay of IL-2 and IL-8 in experimental allergic encephalomyelitis model" @default.
- W2383883947 hasPublicationYear "2000" @default.
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