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- W2383889146 abstract "OBJECTIVE To observe the affection of Leech extract to RF/6A cell by thrombin-induced and to investigate the mechanism of preventive affection of retinal choroidal neovascularization. METHODS RF/6A cell cultured in vitro by digestion culture, and induced by thrombin(20 μ/ml, 2,4,6,8,10,12,24 hour) to observe the express of TNF-α cytokine. Simultaneously, we observed the express of TNF-α by leech extract(64 mg/ml) to RF/6A cell, with or without thrombin-induced. RESULTS The leech extract could decline the TNF-α express of RF/6A cell, with or without thrombin-induced. CONCLUSIONS Leech extract could prevent the retinal vascular disease,from a certain extent, by blocking thrombin activation to reduce retinal angiogenesis factor TNF- α expression to achieve." @default.
- W2383889146 created "2016-06-24" @default.
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- W2383889146 date "2015-01-01" @default.
- W2383889146 modified "2023-09-26" @default.
- W2383889146 title "Effect of leech extract on thrombin induced monkey RF/6A cell in expressing angiogenesis-promoting factor TNF-α" @default.
- W2383889146 hasPublicationYear "2015" @default.
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